23 Jul
Head of Protein Engineering
Vacancy expired!
My client is a rapidly expanding biotech company developing the latest generation of T Cell Immunotherapies. They are currently looking for experienced Scientific Leader to head up their Protein Engineering function.
Responsibilities- Supervision of up to 9 RA and Scientists, leading collaborations for TCR development
- Development of internal platforms, based on affinity maturation of TCRs
- Protein engineering support for lead TCRs identified for T cell therapies with the goal to generate compounds with optimal therapeutic indexes (optimal efficacy and safety characteristics).
- Development of TCR libraries for rapid TCR lead optimization and selection. Continuous optimization of display libraries, library diversity and composition
- Biophysical characterization of lead compounds
- Contributions to regulatory filings of biotherapeutics
- Leading external collaborations as well as interacting with internal and external stakeholders. Regular presentations in front of the board or investors
- 5 to 10 years of industry experience working in Molecular Biology, Protein Engineering, Biochemistry or similar.
- Track record in leading a protein engineering group and contributions to therapeutic compounds advancing to IND filings, clinical trials.
- Engineering of IgGs, VHHs or other scaffolds.
- Phage and/or yeast display technology, mammalian library design and screening, high throughput screening of scFvs, VHHs, Biacore, structure guided protein engineering
- Interaction with CROs and other research organizations
- FACS, T-cell assay development, TCR engineering, strong familiarity with Bioinformatics.
- Based in the Bay Area, California – one of the world largest and most exciting Biotech and Tech hubs
- Competitive salary and benefits package
- Progression opportunities – Chance to get on the ground floor with a well-funded and rapidly expanding Biotech
Vacancy expired!