23 Jul
Head of Protein Engineering
California, Sanfrancisco , 94101 Sanfrancisco USA

Vacancy expired!

My client is a rapidly expanding biotech company developing the latest generation of T Cell Immunotherapies. They are currently looking for experienced Scientific Leader to head up their Protein Engineering function.

Responsibilities
  • Supervision of up to 9 RA and Scientists, leading collaborations for TCR development
  • Development of internal platforms, based on affinity maturation of TCRs
  • Protein engineering support for lead TCRs identified for T cell therapies with the goal to generate compounds with optimal therapeutic indexes (optimal efficacy and safety characteristics).
  • Development of TCR libraries for rapid TCR lead optimization and selection. Continuous optimization of display libraries, library diversity and composition
  • Biophysical characterization of lead compounds
  • Contributions to regulatory filings of biotherapeutics
  • Leading external collaborations as well as interacting with internal and external stakeholders. Regular presentations in front of the board or investors

Skills and Qualifications
  • 5 to 10 years of industry experience working in Molecular Biology, Protein Engineering, Biochemistry or similar.
  • Track record in leading a protein engineering group and contributions to therapeutic compounds advancing to IND filings, clinical trials.
  • Engineering of IgGs, VHHs or other scaffolds.
  • Phage and/or yeast display technology, mammalian library design and screening, high throughput screening of scFvs, VHHs, Biacore, structure guided protein engineering
  • Interaction with CROs and other research organizations
  • FACS, T-cell assay development, TCR engineering, strong familiarity with Bioinformatics.

The Benefits
  • Based in the Bay Area, California – one of the world largest and most exciting Biotech and Tech hubs
  • Competitive salary and benefits package
  • Progression opportunities – Chance to get on the ground floor with a well-funded and rapidly expanding Biotech
If you are looking to take the next step in your career in the Biotech industry and you would like to know more about this role or the other opportunities we currently have on our books, please apply now with your CV to speak with our specialist Scientific Consultant William Ashbrook

Vacancy expired!


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