03 Jul
Postdoctoral Fellow
Texas, Houston , 77001 Houston USA

A postdoctoral position is available in the laboratory of Yonathan Lissanu Deribe, M.D, Ph.D., in the Department of Genomic Medicine and Department of Thoracic Surgery at The University of Texas MD Anderson Cancer Center. Our laboratory focuses on the identification of cancer vulnerabilities and the discovery of novel therapeutics by leveraging our understanding of chromatin biology in cancer development (Lissanu Deribe et al. Nature Medicine 2018, Lissanu Deribe et al. PNAS 2016).https://www.mdanderson.org/research/departments-labs-institutes/labs/lissanu-laboratory.htmlWe utilize genetically engineered mouse (GEM) models of cancer, various functional genomic approaches, including genome-wide CRISPR knockout screens, and immunological and epigenomic technologies such as RNA- Seq, ChIP-Seq, and ATAC-Seq.We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered and patented novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and received several grants to further develop these molecules as cancer therapeutics. (https://patentscope.wipo.int/search/en/detail.jsfdocId=WO2019200217). Excitingly, some of our chemical probes have synergistic anti-tumor efficacy in combination with immunotherapy.The positions will provide deep exposure and training in cancer functional genomics, chromatin biology, cancer immunology, and cancer drug discovery and can be geared to the individual's career goals.We seek highly motivated individuals with a Ph.D. or equivalent degree in all areas of molecular & cell biology, biochemistry, or genetics. Experience with hands-on mice work or computational biology is a big plus but not required.The Lissanu laboratory is a well-funded lab situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated the number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. Competitive salaries and benefits are provided to post-doctoral fellows. Houston is the fourth-largest city in the USA, with a vibrant and booming economy. Houston has a mild winter and is sunny year-round.LEARNING OBJECTIVESUse cutting-edge approaches to seek novel therapeutic targets for human cancers. Be responsible for the design and execution of experimental work, data analysis, and write up Attend and present at internal and international meetings Be expected to publish data in top scientific journalsELIGIBILITY REQUIREMENTSPh.D. or equivalent in Molecular Biology, Biochemistry, Immunology, Genetics, or related field Good publication record Excellent communication skills are required.

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