Scientist - Protein Characterization

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together, we are driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide ouremployees the resources to pursue their goals, both at work and in their personal lives.PositionIn the Molecular and Analytical Development group of BMS, we are a world-class Biophysical and Chemical Characterization Center of Excellence to support the development of life-saving medicines in immuno-oncology and other therapeutic areas. We specialize in biologics development using state of the art biophysical methods to decipher the structural complexities of biological molecules. We foster an innovative and collaborative environment that values and recognizes diversity of contributions, and pushing the limits of technology for analyzing monoclonal antibodies, fusion proteins, and other novel scaffolds progressing in clinical trials for unmet medical needs.The Molecular and Analytical Development group is seeking a highly motivated and creative Biophysical Scientist to analyze structure, stability, and post-translational modifications of proteins to support development of biopharmaceuticals, and be part of the leadership position of BMS in Immuno-Oncology. This individual is also expected to push the limits of advanced biophysical techniques for characterization of therapeutic monoclonal antibodies, antibody drug conjugates, fusion proteins, and other protein modalities.These techniques include, but are not limited to:

spectroscopy (FTIR, Raman, CD, fluorescence, UV/VIS)

analytical ultracentrifugation

microscopy (FTIR, Raman, AFM)

flow-based protein particulate enumeration and imaging (HIAC, MFI, FlowCam)

static and dynamic light scattering

calorimetry (DSC, ITC)

chromatography (SEC, IEX, RP)

capillary electrophoresis (iCIEF, SDS-CGE)

Additional responsibilities include defining critical quality attributes and understanding protein post-translational modifications including degradation pathways in in-vitro systems. He/she is also expected to publish novel findings in journals and present scientific data at internal and external conferences.Responsibilities will also include matrix team leadership. The individual will work independently and in collaboration with colleagues within analytical and across various functional areas to support programs from clinical development through registrational studies.An ideal candidate would have experience with therapeutic proteins including mAb, bispecific antibodies, fusion proteins, antibody drug conjugates and other derivatized proteins, and their structure-function relationships. Proven track record of independent research capability and problem solving ability is required for this position.This individual will be required to interpret and present scientific data, contribute to IND, IMPD, BLA, and other regulatory filings, write technical reports and represent the department in matrix team environment when needed. Attention to detail and be able to work in a highly collaborative environment under tight timelines are required attributes.Bristol-Myers Squibb is an equal opportunity employer - M/F/Vet/DisabilityThe CandidateWe look for scientists who are truly inspired by our mission and who would share our passion for collaborative and entrepreneurial work culture. Because we know that employees are key to our success in bringing novel cancer medicines to patients, we are committed to providing employees with benefits that allow them to bring their best.A PhD in biophysics, biochemistry, physical chemistry, chemical engineering, pharmaceutical science or a related scientific discipline with 0-3 years of relevant experience in biopharmaceutical/biotechnology, or a Masters with a minimum of 5 years of relevant experience is required. Knowledge of protein chemistry, structure, function, and folding are essential. The individual should possess demonstrated skills and proficiency in biophysical techniques including operation, maintenance and troubleshooting of instruments. Familiarity with protein higher order structure analysis, protein particulate techniques such as flow imaging as well as microscopy is a plus. The individual will interface and collaborate with multi-disciplinary teams in a high paced analytical laboratory environment. Excellent communication, interpersonal and organizational skills are essential. Attention to detail and be able to work in a highly collaborative environment under tight timelines is required.Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.Company: Bristol-Myers SquibbReq Number: R1528168ENUpdated: 2020-08-03 00:00:00.000 UTCLocation: New Brunswick,New JerseyBristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.