07 Aug
Senior Scientist
Massachusetts, Westborough 00000 Westborough USA

Vacancy expired!

The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.Astellas is announcing a Senior Scientist opportunity at their affiliate Astellas Institute of Regenerative Medicine (AIRM) in Westborough, MA.Purpose:The Sr. Scientist, in accordance with the strategic goals of the team, utilizes scientific principles and methodologies to perform a variety of laboratory-based experiments and procedures. Coordinates research efforts and makes key technical contribution affecting the direction of the group and/or project. Applies expertise and breadth of knowledge to ongoing research and to the development of new projects.Essential Job Responsibilities:

Maintain multiple iPSC lines and routinely perform differentiation into mesoderm lineages

Viral transduction/engineering of pluripotent stem cell lines and/or their derivatives

Performs data collection, analysis, and interpretation of in vitro assays (e.g. flow cytometry, ICC, ELISA, RT-PCR) to characterize pluripotent stem cell populations and derivatives thereof

Formulates and implements processes ensuring preservation of cellular quality attributes

Isolates, cultures and characterizes primary immune cells from preclinical murine models

Stays up to date on relevant literature and helps manage external collaborations

Develops and adheres to SOPs and workflows with proper documentation

Optimizes procedures as needed, effectively troubleshoots technical issues

Qualifications:Required

D. with 5+years post-degree laboratory experience in developmental biology, cell biology, immunology or related biological life science

Experience with human or mouse pluripotent stem cell culture (ESC or iPSC)

Working knowledge of animal disease models with preference to autoimmune-related disorders

Solid working knowledge of molecular and cell biology techniques and signaling pathways governing stem cell differentiation

Excellent written, verbal communication and interpersonal skills.

Excellent interpersonal skills and ability to work independently and collaborate within a team-based environment

Preferred

Firsthand experience with pluripotent stem cell differentiation into mesoderm lineages

Strong background and interest in working with multiple in vivo, preclinical models

#LI-JA1Equal Opportunity Employer Minorities/Women/Protected Veterans/DisabledCategory Research and Development

Vacancy expired!


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