Analytical Chemist – Oligonucleotide Process Development

POSITION SUMMARY: The Analytical Chemist in Oligonucleotide Process Development develops protocols for the analysis and characterization of individual oligonucleotides and oligonucleotide compositions in an FDA-QSR and ISO9001 compliant organization. Materials created during oligonucleotide development process are used in assay development on feasibility and development stages. Methods and procedures from oligonucleotide development are transferred to oligonucleotide production department.ESSENTIAL JOB RESPONSIBILITIES:

Performs oligonucleotide purification using preparative HPLC instruments

Evaluates and verifies analytical methods for major components and impurities in various chemical compositions

Analyzes and interprets data from the following instruments: HPLC, LC-MS, UPLC-MS, UV-Vis, fluorescent spectroscopy and other methods for reagents characterization

Keeps good laboratory records, document process protocols, create SOPs and worksheets

Teams with manufacturing department on process transfer for developed procedures

TRAINING RESPONSIBILITIES: (REQUIRED)

Complete all assigned and required training satisfactorily and on time

MINIMUM REQUIREMENTS:Education and Experience (in years):

Bachelor’s or Master’s degree in Chemistry/Biochemistry

1-2 years of related work experience in synthesis, purification or analysis of synthetic biomolecules

Knowledge and skills:

In depth understanding of purification and analysis of biomolecules, knowledge of oligonucleotide synthesis, purification and analysis is preferred

Hands-on experience with HPLC, LC-MS, UV-Vis, fluorescence measurements and other analytical methods and instruments, knowledge of UPLC-MS instrumentation is helpful

Excellent writing, communication and organizational skills

Physical requirements/abilities:

Must be able to lift 25 lbs. Must be able to stand for several hours. Work may involve repetitive arm/wrist motions.

Danaher Corporation and all Danaher Companies are equal opportunity employers that evaluate qualified applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law. The “EEO is the Law” poster is available here.