Postdoctoral Research Fellow - Variant-to-Gene Mapping for Common Complex Traits

Reference #: 1010311

SHIFT:Day (United States of America)Seeking Breakthrough MakersChildren's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.CHOP's Commitment to Diversity, Equity, and InclusionCHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.A Brief Overview

A Postdoctoral Fellow is needed to join a dynamic group of investigators interested in studying the functional consequences of signals that have come out of recent genome wide association studies (GWAS), with specific focus on musculoskeletal, addiction, obesity/diabetes and sleep traits. The successful candidate will be dedicated and motivated, and a driver of her/his research. The postdoctoral fellow will be responsible of setting up disease models in human cell lines and iPSC-derived cells, characterize their trait-related phenotypes and manipulate candidate gene expression using CRISPR/Cas9 and/or siRNA or gene overexpression, with the goal of validating novel disease target genes. We are looking for a candidate with strong molecular biology skills and prior experience in either endocrine/neuronal cellular models or iPSC-derived cell biology. Experience in CRISPR/Cas9 genome editing and next-generation sequencing based techniques (such as RNA-seq, ATAC-seq, ChIP-seq) is essential.

For further information contact Struan Grant: grants@chop.edu

What you will do

Conduct independent scholarly research and develop new methods and protocols

Participate in project planning, recording and evaluation of data

Acquire technical, lab management and grant writing skills

Participate in seminars, lectures, poster sessions and presentation at national meetings

Supervise junior lab members

Assist with other research projects

Education Qualifications

Doctorate RequiredMinimum Salary

year 0=$65,000

year 1=$65,500

year2=$66,000

year 3=$66,500

year 4=$67,000To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more.Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.EEO / VEVRAA Federal Contractor | Tobacco StatementChildren's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.