Senior Scientist - Retinal and Vascular Biology

Job DescriptionOur company's Research Laboratories in South San Francisco is a new innovation hub designed to foster partnership between scientists to discover new medicines to improve human health. Retinal and Vascular Biology group, a part of Cardiometabolic Disease Department, is seeking a self-driven and creative Senior Scientist with extensive experience in in vitro and in vivo pharmacology in industry setting. This is an exciting opportunity for an independent bench scientist to drive assay development and optimization to support drug development, target identification and validation activities in close partnership with colleagues in the group, department, Research and Development Division South San Francisco and across broader company network.The ideal candidate will be an accomplished scientist with minimum of 5-7 years industry experience with demonstrated proficiency in in vitro and in vivo assay development and optimization in retinal and/or vascular diseases. This position requires high level of motivation and dedication to lab experimentation with excellent comprehension of molecular biology, cell signaling pathways, retinal and vascular biology.Education Minimum Requirement

BS or MS degree in cell biology, molecular biology, neuroscience, or related biological discipline with minimum 8-10 (BS) or 5-7 (MS) years respectively of relevant professional laboratory research experience.

Specific Responsibilities:

Employ innovative molecular and cell biology platforms to advance target validation and drug discovery efforts

Collaborate with multiple stakeholders directly contributing to drug discovery efforts to address high unmet medical need in retinal and vascular disease.

In vitro and in vivo assay development and optimization in retinal and/or vascular diseases.

Drive assay development and optimization to support drug development, target identification and validation activities in close collaboration with colleagues in the group, department, Research and Development Division South San Francisco and across broader company network.

Required skills:

Hands on experience with building in vitro biochemical and cell-based assays utilizing state-of-art technologies

Technical expertise and experience in pre-clinical ophthalmology in vivo techniques including FA, OCT, ERG and ocular injections

Ability to independently design, conduct, troubleshoot, and analyze experimental data for target identification and validation purpose

Demonstrated ability to learn, understand and independently implement new techniques or platforms

Commitment to experimental excellence and scientific rigor

Proficiency in using professional data analysis and visualization software such as Spotfire, Excel and GraphPad Prism

Excellent oral and written communication and presentation skills

Strong motivation and passion for science

Strong technical proficiency in assay development

High level of organizational skills to support multiple projects in matrix environment

Preferred skills

Experience in culturing human endothelial cells

Experience in handling and processing ex-vivo tissue samples for downstream in vitro analysis

Knowledge and experience in retinal and/or vascular biology

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Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. 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We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)U.S. Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.Expected US salary range:$125,000.00 - $196,800.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here (https://www.benefitsatmerck.com/) .Search Firm Representatives Please Read CarefullyMerck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.Employee Status:RegularRelocation:DomesticVISA Sponsorship:YesTravel Requirements:10%Flexible Work Arrangements:Not ApplicableShift:Not IndicatedValid Driving License:NoHazardous Material(s):Bloodborne pathogens, OEB4, beta lactamJob Posting End Date:10/4/2024A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.Job Posting End Date: 10/04/2024A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.Requisition ID: R314459